- Casbane Diterpene as a Promising Natural Antimicrobial Agent against Biofilm-Associated Infections
- Is Interexperiment
- 29/04/2014 19:04:20
- Maria Olivia Pereira
- Experiment accepted
This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms.
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|antimicrobial agent||casbane diterpene||NULL|
|medium||tryptic soy broth||NULL|
|device||96-well microtiter plate||NULL|
cristal violet assay - -
|antimicrobial agent||casbane diterpene||μg/mL|
|organism||Escherichia coli CECT 434, Escherichia coli K12, Klebsiella oxytoca ATCC 13182, Klebsiella pneumoniae ATCC 11296, Pseudomonas aeruginosa ATCC 10145, Pseudomonas aeruginosa CGCT 111, Pseudomonas fluorescens ATCC 13525, Staphylococcus aureus undefined, Staphylococcus epidermidis CECT 231, Staphylococcus epidermidis CECT 4183||NULL|
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