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Experiment

Id
 
Name
Casbane Diterpene as a Promising Natural Antimicrobial Agent against Biofilm-Associated Infections  
Is Interexperiment
compoundExperimentNo  
Created
30/12/2010  
Published
Contributors
Maria Olivia Pereira  
State
Experiment accepted

Description

This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms.

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Conditions

Name Value Units
antimicrobial agent casbane diterpene NULL
shear force 120 rpm
medium tryptic soy broth NULL
device 96-well microtiter plate NULL
temperature 37 ºc

Methods

cristal violet assay - -

Name Value Units
antimicrobial agent casbane diterpene μg/mL
organism Escherichia coli CECT 434, Escherichia coli K12, Klebsiella oxytoca ATCC 13182, Klebsiella pneumoniae ATCC 11296, Pseudomonas aeruginosa ATCC 10145, Pseudomonas aeruginosa CGCT 111, Pseudomonas fluorescens ATCC 13525, Staphylococcus aureus undefined, Staphylococcus epidermidis CECT 231, Staphylococcus epidermidis CECT 4183 NULL
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