- Farnesol as antibiotics adjuvant in Staphylococcus epidermidis control in vitro
- Is Interexperiment
- 29/04/2014 19:04:25
- Pilar Teixeira
- Experiment accepted
The goal of this study was to compare the in vitro postantimicrobial effect (PAE) of farnesol against Staphylococcus epidermidis with the corresponding values of most common practice antibiotics and also to evaluate the combined effect of farnesol with these antibiotics against planktonic and biofilm cells. Farnesol showed a combined effect with the tested antibiotics against planktonic cells, although this was not so evident against biofilm cells. Despite the reduced efficacy against biofilm cells, farnesol seems to be a potential adjuvant therapeutic agent to antibiotics against S epidermidis planktonic cells. Moreover, its long PAE makes farnesol a potential candidate in the prevention of biofilm formation because it showed to be very effective against planktonic cells alone as well.
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|medium||tryptic soy broth||NULL|
|device||96-well microtiter plate||NULL|
colony-forming unit - -
|antimicrobial agent||vancomycin, tetracycline||NULL|
|organism||Staphylococcus epidermidis 1457, Staphylococcus epidermidis 9142||NULL|
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