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Experiment

Id
 
Name
Farnesol as antibiotics adjuvant in Staphylococcus epidermidis control in vitro  
Is Interexperiment
compoundExperimentNo  
Created
29/02/2020  
Published
Contributors
Pilar Teixeira  
State
Experiment accepted

Description

The goal of this study was to compare the in vitro postantimicrobial effect (PAE) of farnesol against Staphylococcus epidermidis with the corresponding values of most common practice antibiotics and also to evaluate the combined effect of farnesol with these antibiotics against planktonic and biofilm cells. Farnesol showed a combined effect with the tested antibiotics against planktonic cells, although this was not so evident against biofilm cells. Despite the reduced efficacy against biofilm cells, farnesol seems to be a potential adjuvant therapeutic agent to antibiotics against S epidermidis planktonic cells. Moreover, its long PAE makes farnesol a potential candidate in the prevention of biofilm formation because it showed to be very effective against planktonic cells alone as well.

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Conditions

Name Value Units
shear force 130 rpm
medium tryptic soy broth NULL
device 96-well microtiter plate NULL
temperature 37 ºc

Methods

colony-forming unit - -

Name Value Units
antimicrobial agent vancomycin, tetracycline NULL
antimicrobial agent farnesol μM
organism Staphylococcus epidermidis 1457, Staphylococcus epidermidis 9142 NULL
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